abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:We seek to describe the procedure, complications, and functional outcomes of utilizing the cecum and ascending colon for creation of a neovagina on a gynecologic oncology service. METHODS:A search of all the cases on the gynecologic oncology service over a ten year period yielded fourteen cases of cecal neov...

journal_title：Gynecologic oncology

authors： Khulpateea BR,Silver DF

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Limited knowledge exists about the value of tumor size in surgically treated cervical cancer (CX) using a tumor size of 2 cm as cut-off value. METHODS:A total of 366 cases of CX FIGO stage IB who received upfront surgery were evaluated regarding tumor size, the prediction of pelvic lymph node involvement, a...

journal_title：Gynecologic oncology

authors： Horn LC,Bilek K,Fischer U,Einenkel J,Hentschel B

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of introducing a robotics program on clinical outcome of elderly patients with endometrial cancer. METHODS:Evaluation and comparison of peri-operative morbidity and disease-free interval in 163 consecutive elderly patients (≥70years) with endometrial cancer undergoing staging procedure...

journal_title：Gynecologic oncology

authors： Lavoue V,Zeng X,Lau S,Press JZ,Abitbol J,Gotlieb R,How J,Wang Y,Gotlieb WH

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to establish a reference 24-hour urine human chorionic gonadotropin (hCG) regression curve in patients with complete hydatidiform mole (CHM) as diagnostic tool in the prediction of persistent trophoblastic disease (PTD). METHODS:From 2004 to 2011, 312 cases suitable for this study w...

journal_title：Gynecologic oncology

authors： van Cromvoirt SM,Thomas CM,Quinn MA,McNally OM,Bekkers RL

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The identification and investigation of cancer-associated long non-coding RNAs are important for understanding the molecular biology of cancer. The aim of the present study was to examine the expression pattern of lncRNA XLOC_010588 in cervical cancer and to evaluate its biological role and clinical significa...

journal_title：Gynecologic oncology

authors： Liao LM,Sun XY,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng M,Huang L

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To determine whether chemotherapy-induced neutropenia (C-iN) is associated with improved survival in a population of primary advanced ovarian cancer and peritoneal carcinoma patients treated with a carboplatin plus paclitaxel chemotherapy backbone. METHODS:A post-hoc exploratory analysis of Gynecologic Oncol...

journal_title：Gynecologic oncology

authors： Tewari KS,Java JJ,Gatcliffe TA,Bookman MA,Monk BJ

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:To compare survival of Hispanic white (HW) and non-Hispanic white (NHW) women with type II endometrial adenocarcinoma (EC). METHODS:Patients with serous, clear cell or grade 3 endometrioid EC were identified from the Surveillance, Epidemiology, and End Results (SEER) program 1988-2009 and were divided into ...

journal_title：Gynecologic oncology

authors： Mahdi H,Hou H,Kowk LL,Moslemi-Kebria M,Michener C

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the impact of introducing HR-HPV testing in cytology regarding cervical cancer screening practice. METHODS:A pooled analysis of liquid-based cytology (LBC) and HR-HPV testing using data from 13 population-based cervical cancer screening studies conducted in China w...

journal_title：Gynecologic oncology

authors： Pan QJ,Hu SY,Guo HQ,Zhang WH,Zhang X,Chen W,Cao J,Jiang Y,Zhao FH,Qiao YL

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Differentiation between grade-1 endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is crucial to determine optimal surgical management. However, discrepancies exist between preoperative diagnosis of AEH and final histology. Our aim was to establish clusters of immunohistochemical markers to d...

journal_title：Gynecologic oncology

authors： Laas E,Ballester M,Cortez A,Gonin J,Daraï E,Graesslin O

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Endometrial cancer mortality disproportionately affects black women and whether greater prevalence of obesity plays a role in this disparity is unknown. We examine the effect of race on post-surgical complications, length of stay, and mortality specifically in a morbidly obese population. METHODS:Black and w...

journal_title：Gynecologic oncology

authors： Cote ML,Ruterbusch JJ,Ahmed Q,Bandyopadhyay S,Alosh B,Abdulfatah E,Seward S,Morris R,Ali-Fehmi R

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Links between obesity, with its attendant estrogen abnormalities, and the endometrial carcinoma (EC) DNA Mismatch Repair Protein (MMR) system have recently been proposed. We investigated relationships between body mass index (BMI) and clinicopathological correlates including MMR expression in a large single i...

journal_title：Gynecologic oncology

authors： Joehlin-Price AS,Perrino CM,Stephens J,Backes FJ,Goodfellow PJ,Cohn DE,Suarez AA

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To develop a nomogram to predict overall survival (OS) in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy. METHODS:A multicenter retrospective study was conducted. Potential prognostic variables included age; stage; grade; histology; performance status; residual disease; presenc...

journal_title：Gynecologic oncology

authors： Previs RA,Bevis KS,Huh W,Tillmanns T,Perry L,Moore K,Chapman J,McClung C,Kiet T,Java J,Chan J,Secord AA

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Caregiver burden, quality of life (QOL) and unmet needs are poorly understood, particularly at the end of life. We explored these issues in caregivers of women with ovarian cancer. PATIENTS AND METHODS:The Australian Ovarian Cancer Study (AOCS) is a prospective population-based study of women newly diagnosed w...

journal_title：Gynecologic oncology

authors： Butow PN,Price MA,Bell ML,Webb PM,deFazio A,Australian Ovarian Cancer Study Group.,Australian Ovarian Cancer Study Quality Of Life Study Investigators.,Friedlander M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is the leading cause of death in women with gynecologic cancer. CA125 is the commonly used biomarker in the diagnosis of ovarian cancer, but has limitations in both sensitivity and specificity. Human Epididymal secretory protein (HE4) is a promising biomarker and is included in the Risk of Ovar...

journal_title：Gynecologic oncology

authors： Stiekema A,Lok CA,Kenter GG,van Driel WJ,Vincent AD,Korse CM

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To evaluate, from a societal perspective, the cost-effectiveness of adding bevacizumab to first-line therapy based on outcomes from the GOG-218 and ICON-7 trials. METHODS:A three-state Markov model was used. The time horizon was until the death of 99% of the initial cohort of 1000 individuals. Costs and qual...

journal_title：Gynecologic oncology

authors： Mehta DA,Hay JW

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To investigate the neutrophil-to-lymphocyte ratio (NLR) from peripheral blood, a general measure of inflammation, in ovarian cancer. METHODS:White cell counts and CA125 levels before treatment, tumor features, and questionnaire data on 519 women with ovarian cancer at two Boston hospitals were recorded. Coun...

journal_title：Gynecologic oncology

authors： Williams KA,Labidi-Galy SI,Terry KL,Vitonis AF,Welch WR,Goodman A,Cramer DW

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The consequences of defective homologous recombination and other DNA repair pathways are important in disease outcomes of numerous tumor types. The objective of this study was to explore BRCA1, PARP, FANCD2, PTEN, H2AX, and ATM protein expression in endometrial cancer (EC). METHODS:PARP1, γH2AX, ATM, FANCD2,...

journal_title：Gynecologic oncology

authors： Mhawech-Fauceglia P,Wang D,Kim G,Sharifian M,Chen X,Liu Q,Lin YG,Liu S,Pejovic T

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. METHODS:We retrospectively re...

journal_title：Gynecologic oncology

authors： So KA,Hong JH,Jin HM,Kim JW,Song JY,Lee JK,Lee NW

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:In vitro data and pilot data suggest that green tea catechins may possess chemopreventive activity for cervical cancer and precursor lesions. We conducted a randomized, double-blind, placebo-controlled trial of Polyphenon E (decaffeinated and enriched green tea catechin extract) in women with persistent human...

journal_title：Gynecologic oncology

authors： Garcia FA,Cornelison T,Nuño T,Greenspan DL,Byron JW,Hsu CH,Alberts DS,Chow HH

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

journal_title：Gynecologic oncology

authors： Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:In Denmark, the proportion of women with ovarian cancer treated with neoadjuvant chemotherapy (NACT) has increased, and the use of NACT varies among center hospitals. We aimed to evaluate the impact of first-line treatment on surgical outcome and median overall survival (MOS). METHODS:All patients treated in...

journal_title：Gynecologic oncology

authors： Fagö-Olsen CL,Ottesen B,Kehlet H,Antonsen SL,Christensen IJ,Markauskas A,Mosgaard BJ,Ottosen C,Soegaard CH,Soegaard-Andersen E,Hoegdall C

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The origins and clinical significance of endosalpingiosis (ES), ectopic tubal epithelium, are not well understood. These investigations aim to characterize ES as it relates to normal fallopian tube, ovarian surface and serous neoplasms. METHODS:A retrospective review of pathology reports from all prophylacti...

journal_title：Gynecologic oncology

authors： Esselen KM,Ng SK,Hua Y,White M,Jimenez CA,Welch WR,Drapkin R,Berkowitz RS,Ng SW

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to compare survival of Asian (AS), American Indian/Alaskan Native (AI/AN) and non-Hispanic white (NHW) women with endometrial adenocarcinoma (EC). METHODS:Patients with EC were identified from the Surveillance, Epidemiology, and End Results program from 1988 to 2009. Kaplan-Mei...

journal_title：Gynecologic oncology

authors： Mahdi H,Schlick CJ,Kowk LL,Moslemi-Kebria M,Michener C

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Most women with ovarian cancer relapse and undergo further chemotherapy however evidence regarding the benefits of this for women with platinum-resistant disease is limited. Our objective was to determine whether there was a quality of life improvement or treatment response among women treated for platinum-re...

journal_title：Gynecologic oncology

authors： Beesley VL,Green AC,Wyld DK,O'Rourke P,Wockner LF,deFazio A,Butow PN,Price MA,Horwood KR,Clavarino AM,Australian Ovarian Cancer Study Group,Australian Ovarian Cancer Study-Quality Of Life Study Investigators,Webb PM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the relationship between 13 proteins involved in DNA damage and the outcomes of patients with recurrent ovarian cancer (ROC). PATIENTS AND METHODS:Immunohistochemistry staining was performed in 114 diagnostic samples from patients with serous ROC who participated in the OVA-301 study,...

journal_title：Gynecologic oncology

authors： Monk BJ,Kaye SB,Poveda A,Herzog TJ,Aracil M,Nieto A,Badri N,Parekh TV,Tanović A,Galmarini CM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Most borderline ovarian tumors (BOTs) are cured with surgery. However BOTs with invasive implants have a poor prognosis with a mortality of 20-40%. The benefit of adjuvant chemotherapy (CT) in this setting remains poorly defined. METHODS:Retrospective study of serous BOT+invasive implants treated with adjuv...

journal_title：Gynecologic oncology

authors： Leary A,Petrella MC,Pautier P,Duvillard P,Uzan C,Tazi Y,Ledoux F,Gouy S,Morice P,Lhommé C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:We previously reported high rates of urinary incontinence among gynecologic cancer survivors and aimed to evaluate the effectiveness of a simple intervention for treatment of urinary incontinence in this population. METHODS:We recruited 40 gynecologic cancer survivors who reported urinary incontinence on a ...

journal_title：Gynecologic oncology

authors： Rutledge TL,Rogers R,Lee SJ,Muller CY

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Survivorship and quality of life issues are becoming increasingly relevant in endometrial cancer as a result of the marked increase in incidence of the disease combined with excellent and improving long term survival. OBJECTIVE:The purpose of this study was to evaluate the effect of obesity on quality of li...

journal_title：Gynecologic oncology

authors： Smits A,Lopes A,Das N,Bekkers R,Galaal K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

journal_title：Gynecologic oncology

authors： Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

journal_title：Gynecologic oncology

authors： English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Some authors have recommended the use of diagnostic laparoscopy as a pretreatment assessment step for conservative hormonal treatment in young women with endometrial cancer. The aim of this study was to determine the incidence of synchronous primary cancer of the endometrium and ovary in young women. METHODS...

journal_title：Gynecologic oncology

authors： Song T,Seong SJ,Bae DS,Suh DH,Kim DY,Lee KH,Lim MC,Lee TS

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Diagnosis and treatment for a life threatening illness such as cancer are known to be psychologically impactful. However, little is known about the influence that non-cancer life stressors have on the quality of life (QOL) of ovarian cancer patients. The goal of the present study was to examine associations ...

journal_title：Gynecologic oncology

authors： Lutgendorf SK,Slavich GM,Degeest K,Goodheart M,Bender D,Thaker PH,Penedo F,Zimmerman B,Lucci J 3rd,Mendez L,Collins K,Sood AK

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To determine the impact of venous thromboembolism (VTE) during primary treatment of ovarian clear cell carcinoma (OCCC) on survival. METHODS:After Institutional Review Board approval, 74 cases of OCCC were retrieved from our pathology files. Clinical and pathological data were obtained by medical record and...

journal_title：Gynecologic oncology

authors： Diaz ES,Walts AE,Karlan BY,Walsh CS

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:The concept of "platinum sensitivity" has been widely applied in the management of recurrent ovarian cancer. This study aimed to evaluate the applicability of this concept to recurrent endometrial cancer. PATIENTS AND METHODS:In this multicenter retrospective cohort study, the clinical data of patients with ...

journal_title：Gynecologic oncology

authors： Nagao S,Nishio S,Michimae H,Tanabe H,Okada S,Otsuki T,Tanioka M,Fujiwara K,Suzuki M,Kigawa J

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Use of in vitro chemoresponse assays for informing effective treatment selection is a compelling clinical question and a topic of debate among oncologists. A prospective study was conducted evaluating the use of a chemoresponse assay in recurrent ovarian cancer patients. METHODS:Women with persistent or recu...

journal_title：Gynecologic oncology

authors： Rutherford T,Orr J Jr,Grendys E Jr,Edwards R,Krivak TC,Holloway R,Moore RG,Puls L,Tillmanns T,Schink JC,Brower SL,Tian C,Herzog TJ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

journal_title：Gynecologic oncology

authors： Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To quantify the impact of preoperative hypoalbuminemia on 30-day mortality and morbidity after gynecologic cancer surgery. METHODS:Patients included in the National Surgical Quality Improvement Program (NSQIP) dataset who underwent any non-emergent surgery for gynecologic malignancy between 1/1/2008 and 12/3...

journal_title：Gynecologic oncology

authors： Uppal S,Al-Niaimi A,Rice LW,Rose SL,Kushner DM,Spencer RJ,Hartenbach E

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC). METHODS:The best candidates from fine-mapping analysis of 2...

journal_title：Gynecologic oncology

authors： Johnatty SE,Beesley J,Gao B,Chen X,Lu Y,Law MH,Henderson MJ,Russell AJ,Hedditch EL,Emmanuel C,Fereday S,Webb PM,Australian Ovarian Cancer Study Group.,Goode EL,Vierkant RA,Fridley BL,Cunningham JM,Fasching PA,Beckmann

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the optimal cytoreduction (OPT) rate, National Comprehensive Cancer Network (NCCN) treatment guideline compliance rate and patient outcomes for advanced stage epithelial ovarian cancer (EOC) patients at our low volume institution. METHODS:Following IRB approval, records of patients with Stage III...

journal_title：Gynecologic oncology

authors： Phippen NT,Barnett JC,Lowery WJ,Miller CR,Leath CA 3rd

更新日期：2013-10-01 00:00:00